This tool does not provide medical advice. Continued What Are the Potential Side Effects of Savella? Results of in vitro studies demonstrate that duloxetine does not inhibit activity. What happens if I miss a dose Cymbalta? lamisil
When a drug flyer says, "Taper off slowly. National Institute of Mental Health. Depression and Chronic Pain. Orally administered duloxetine hydrochloride is well absorbed. There is a median 2 hour lag until absorption begins T lag with maximal plasma concentrations Cmax of duloxetine occurring 6 hours post dose. Food does not affect the Cmax of duloxetine, but delays the time to reach peak concentration from 6 to 10 hours and it marginally decreases the extent of absorption AUC by about 10%. There is a 3 hour delay in absorption and a one-third increase in apparent clearance of duloxetine after an evening dose as compared to a morning dose.
The FDA approved Cymbalta for based on two that together included 874 fibromyalgia patients, according to Lilly. The most commonly reported side effects reported in placebo-controlled clinical trials as a reason for treatment discontinuation and considered to be drug-related included nausea, dizziness, somnolence, headache, and fatigue. How should I take Cymbalta? How should I store Cymbalta?
After 12 weeks of treatment, the results showed those treated with Cymbalta had a significantly greater reduction in average pain, as measured by the Brief Pain Inventory. They also experienced greater improvement in their own perception of their low back pain and its severity and interference with their daily lives. Savella is a tablet. You take Savella in two divided doses each day. Hyponatremia - Advise patients that hyponatremia has been reported as a result of treatment with SNRIs and SSRIs, including CYMBALTA. Following is a list of treatment-emergent adverse reactions reported by patients treated with CYMBALTA in clinical trials.
Doses statistically significantly superior to placebo. AFTER I've stayed up a few nights. It just happens out of the blue. Physical therapy is often recommended to help ease fibromyalgia pain and teach self-management skills. Learn more about the different types of physical therapy for fibromyalgia. Patients with clinically evident hepatic impairment have decreased duloxetine metabolism and elimination. After a single 20 mg dose of CYMBALTA, 6 cirrhotic patients with moderate liver impairment Child-Pugh Class B had a mean plasma duloxetine clearance about 15% that of age-and gender-matched healthy subjects, with a 5-fold increase in mean exposure AUC. The efficacy of CYMBALTA for the management of neuropathic pain associated with diabetic was established in 2 randomized, 12-week, double-blind, placebo-controlled, fixed-dose studies in adult patients having diabetic peripheral neuropathic pain for at least 6 months. Study DPNP-1 and Study DPNP-2 enrolled a total of 791 patients of whom 592 75% completed the studies. Patients enrolled had Type I or II with a diagnosis of painful symmetrical sensorimotor polyneuropathy for at least 6 months. Blue No. 2, gelatin, hypromellose, hydroxypropyl methylcellulose acetate succinate, sodium lauryl sulfate, sucrose, sugar spheres, talc, titanium dioxide, and triethyl citrate. The 20 and 60 mg capsules also contain iron oxide yellow. What other drugs will affect duloxetine Cymbalta? May cause a lowering of blood pressure - this may be particularly noticeable when going from a sitting to standing position. May also increase blood pressure in some people. CYMBALTA should be swallowed whole and should not be chewed or crushed, nor should the capsule be opened and its contents be sprinkled on food or mixed with liquids. All of these might affect the enteric coating.
Who should not take Cymbalta? In another study, 887 patients meeting DSM-IV-TR criteria for GAD received CYMBALTA 60 mg to 120 mg once daily during an initial 26-week open-label treatment phase. Subgroup analyses did not indicate that there were differences in treatment outcomes as a function of NSAIDs use. I'll bet THEY don't take them! The good part is that at least I'm not crazy and I'm not alone. If anyone else has any ideas to help through the process I would appreciate it. Thank you! Unless you are totally immobilized from a back injury, your doctor probably will test your range of motion and nerve function and press on your back to locate the area of discomfort. Pupillary dilation that occurs following the use of many antidepressant drugs may trigger an angle closure attack in a patient with anatomically narrow angles who does not have a patent iridectomy. The proposed mechanism for the development of hyponatremia involves the syndrome of inappropriate secretion of antidiuretic hormone SIADH via release of antidiuretic hormone. CYMBALTA was discontinued. Elderly patients may be at greater risk of developing hyponatremia with SSRIs and SNRIs. What happens if I overdose Cymbalta? Drugs that raise the gastrointestinal pH may lead to an earlier release of duloxetine. However, co-administration of CYMBALTA with aluminum-and magnesium-containing 51 mEq or CYMBALTA with famotidine, had no significant effect on the rate or extent of duloxetine absorption after administration of a 40 mg oral dose. Some of the side effects that can occur with duloxetine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. Aggression and anger have been reported particularly early in treatment or after treatment discontinuation. Side Effects List Cymbalta side effects by likelihood and severity. Suicidal Thoughts and Behaviors - Encourage patients, their families, and their caregivers to be alert to the emergence of anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia psychomotor restlessness hypomania, mania, other unusual changes in behavior, worsening of depression, and suicidal ideation, especially early during antidepressant treatment and when the dose is adjusted up or down. lotriderm
Efficacy was not demonstrated in two 10-week, placebo-controlled trials with 800 pediatric patients with MDD, age 7 to 17. Neither CYMBALTA nor an active control indicated for treatment of pediatric depression was superior to placebo. The safety and effectiveness in pediatric patients less than 7 years of age have not been established. Hg diastolic in placebo-treated patients. There was no significant difference in the frequency of sustained 3 consecutive visits elevated blood pressure. In a clinical study designed to evaluate the effects of CYMBALTA on various parameters, including blood pressure at supratherapeutic doses with an accelerated dose titration, there was evidence of increases in blood pressure at doses up to 200 mg twice daily. CYMBALTA. Syncope and orthostatic tend to occur within the first week of therapy but can occur at any time during CYMBALTA treatment, particularly after dose increases. The risk of falling appears to be related to the degree of orthostatic decrease in blood pressure as well as other factors that may increase the underlying risk of falls. It may take 4 weeks or longer before your symptoms improve. Keep using the medication as directed. Do not stop using duloxetine without first talking to your doctor. You may have unpleasant side effects if you stop taking this medication suddenly. Depression and Antidepressants: Options, Advantages, and Precautions. Nov 2013. X-rays are useful in pinpointing broken bones or other skeletal defects. To analyze soft-tissue damage such as disk herniation, scans may be needed. terbinafine alternative canada terbinafine
Stopping an antidepressant medicine suddenly can cause other symptoms. It could seriously harm the person you give it to, and sharing it is against the law. When back pain is chronic, pain modifying medications, such as the may be helpful. Cymbalta, a serotonin-norepinephrine reuptake inhibitor, or SNRI, is FDA approved for the treatment of related to the muscles and skeleton, including pain from and chronic lower back. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. In post marketing experience, cases of urinary retention have been observed. Plasma TCA concentrations may need to be monitored and the dose of the TCA may need to be reduced if a TCA is co-administered with CYMBALTA. Norman TR, Olver JS. Duloxetine in the treatment of generalized anxiety disorder. Neuropsychiatr Dis Treat. Cymbalta as long as I've been. Omega's. I drank between 1 - 2 gallons of water per day to ensure I kept my system flushed. What should I avoid while taking duloxetine Cymbalta? WARNING you about "WITHDRAWAL" just like a "junkie. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. femara order pharmacy uk
These changes may cause you to be more sensitive to pain. This could result from the wrong levels of neurotransmitters. Those treated with Cymbalta also reported a greater reduction in their perception of their low back pain and its interference in their daily lives. I'm so tired of not being able to get my thoughts, my house, my bills, my time. FDA. Living with Fibromyalgia, Drugs Approved to Manage Pain. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. If you become pregnant while taking Cymbalta, talk to your healthcare provider aboutregistering with the Cymbalta Pregnancy Registry. You can register by calling 1-866-8146975 or by visiting www. No suicides occurred in any of the pediatric trials. There were suicides in the adult trials, but the number was not sufficient to reach any conclusion about drug effect on suicide. Nausea imm. went away. No specific pharmacokinetic study was conducted to investigate the effects of race. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. In the US, the FDA recommends flushing this down the toilet or pouring into a drain. Consult your or local waste disposal company. Eli Lilly divulging the facts about what exactly would be happening to me in the future? How Is Back Pain Diagnosed? Ask your doctor or pharmacist about other ways to decrease such as lying down for 1 to 2 hours with as little head movement as possible. If nausea persists, see your doctor. Swallow CYMBALTA whole. Do not chew or crush. Do not open the capsule and sprinkle its contents on food or mix with liquids. All of these might affect the coating. CYMBALTA can be given without regard to meals. If a dose of CYMBALTA is missed, take the missed dose as soon as it is remembered. If it is almost time for the next dose, skip the missed dose and take the next dose at the regular time. Do not take two doses of CYMBALTA at the same time. salbutamol generic prices salbutamol
Many postings are not sensitive to these facts. For instance, some are more stimulating and better with lethargy, some are more sedating and better with anxiety. Beware of the negative postings for any of the antidepressants which say things like: drug should be banned, had a terrible time coming off the med, etc. When CYMBALTA and ethanol were administered several hours apart so that peak concentrations of each would coincide, CYMBALTA did not increase the impairment of mental and motor skills caused by alcohol. There is a pregnancy registry that monitors the pregnancy outcomes in women exposed to CYMBALTA during pregnancy. To enroll, contact the CYMBALTA Pregnancy Registry at 1-866-814-6975 or www. Cymbalta can pass into your breast milk. Talk to your healthcare provider about the best way to feed your baby while taking Cymbalta. PLEASE don't take anything without checking it out THOROUGHLY on this website because your doctors might not know or even tell you about the withdrawal. For various degrees of improvement in pain from baseline to study endpoint, Figures 7 and 8 show the fraction of patients in CLBP-1 and CLBP-3 achieving that degree of improvement. The figures are cumulative, so that patients whose change from baseline is, for example, 50%, are also included at every level of improvement below 50%. Patients who did not complete the study were assigned the value of 0% improvement. What should I discuss with my healthcare provider before taking duloxetine Cymbalta? Dosage adjustment based on gender is not necessary.
It may slow recovery and cause new problems. In most cases, you will be expected to start normal, nonstrenuous activity such as walking within 24 hours to 72 hours. After that, controlled exercise or may be helpful. My mom is on 120 mgs a day taking 60 morning and night for fibromyalgia. They doubled her from 60 to 120 when she was having panic attacks. Which were probably side affects and now the doctor made it worse by giving her more. NSAIDs-use status. Patients assigned to CYMBALTA started treatment in both studies at a dose of 30 mg once daily for one week. After the first week, the dose of CYMBALTA was increased to 60 mg once daily. CYMBALTA, which may be signs of liver problems. Instruct patients to talk to their healthcare provider about their alcohol consumption. These improvements were reported in measurements of pain, and mental state. Before using this medication, women of childbearing age should talk with their doctors about the risks and benefits. Tell your doctor if you are or if you plan to become pregnant. National Sleep Foundation. Fibromyalgia and Sleep. Many drugs can interact with duloxetine. Not all possible interactions are listed here. Patients were permitted up to 4 g of per day as needed for pain, in addition to CYMBALTA. Patients recorded their pain daily in a diary. And the emotional roller coaster of feeling like the world is against you. and have tears for no reasons. THEN BY ALL MEANS. Caucasian for MDD, GAD, OA and CLBP, DPNP, and FM, respectively. Treatment with Cymbalta also had a slight, but not significant, effect on disability scores. eref.info silagra
Monitor your blood pressure before starting and throughout treatment. Some of these side effects may decrease after you have been using this for a while. If any of these effects persist or worsen, tell your doctor or promptly. Advise patients of the following issues and ask them to alert their prescriber if these occur while taking CYMBALTA. Combining these with Savella may increase your risk of abnormal bleeding. Each person reacts individually to the positive and negative effects of antidepressants. Statistically, they all have about the same success rate but which ones work for one person is individual and so are the side effects. buy generic duloxetine shopping
Interference with Psychomotor Performance - Any psychoactive drug may impair judgment, thinking, or motor skills. Although in controlled studies CYMBALTA has not been shown to impair psychomotor performance, function, or memory, it may be associated with sedation and dizziness. Therefore, caution patients about operating hazardous machinery including automobiles, until they are reasonably certain that CYMBALTA therapy does not affect their ability to engage in such activities. Unfortunately, there is not always a direct correlation between the findings on imaging studies and the amount of back pain. Many people have findings on CT scans and MRI, yet do not have back pain. What Are the Treatments for Back Pain? What are the possible side effects of Cymbalta? The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Do not start CYMBALTA in a patient who is being treated with linezolid or intravenous methylene blue because there is an increased risk of serotonin syndrome. Patients using Cymbalta may experience orgasm problems, such as not being able to reach orgasm or having difficulty reaching orgasm. Men experienced difficulty with the ability to reach orgasms during four clinical trials designed to identify and measure sexual side effects, states RxList. Antidepressant medicines have other side effects. Talk to your healthcare provider about theside effects of the medicine prescribed for you or your family member. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. About a million people have taken Cymbalta since the drug's approval in 2004, according to Lilly's letter. price cozaar dose pack
Based on my research, once I reach 30 days off Cymbalta I will begin introducing L-Tryptophan and L-Tyrosine into my diet, tapering up at first, and dosing strategically throughout the day. At first I contemplated using 5-HTP for mood enhancement, but there were significant studies that show L-Tryptophan to be far superior for what I'm looking to accomplish. In the study, presented at the annual meeting of the American Academy of Pain Medicine in San Antonio, researchers compared the effects of treatment with 60 milligrams of Cymbalta once a day or a placebo in 401 adults with chronic low back pain. Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor antidepressant SSNRI. Duloxetine affects chemicals in the brain that may become unbalanced and cause depression. Subgroup analyses did not indicate that there were any differences in treatment outcomes as a function of age or gender. You have to stay active. I know it sounds daunting but I forced myself on the treadmill for 30 minutes every morning. I also found that socializing helped, which was ironic because the absolute last thing I wanted to do was be social. Orthostatic hypotension and syncope tend to occur within the first week of therapy; however, they may occur at any time during treatment, particularly after dose increases. The risk of blood pressure decreases may be greater when duloxetine the active ingredient contained in Cymbalta is given concomitantly with drugs that may induce orthostatic hypotension, such as antihypertensives, with potent CYP450 1A2 inhibitors, or with duloxetine doses above 60 mg per day. Hg diastolic up to 12 hours after dosing. He's depressed all the time and won't take anything just like his father and his father's father committed suicide. Tell your doctor if your pain persists or worsens. Our Cymbalta Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. bactrim
Because duloxetine is highly bound to plasma protein, administration of CYMBALTA to a patient taking another drug that is highly protein bound may cause increased free concentrations of the other drug, potentially resulting in adverse reactions. They drs feed us this bull everyday and get you hooked then want to expermint. so they give you more. then your hook. Ive never got hooked on percs or weed like Cymbalta. Ive never had the side effects like cymbalta. I fight it everyday and will keep fighting it til i can pull myself away from it. Good luck to everyone on it. and please try to get off of it asap. it will ruin your life. Before i go i want to stand up for myself and let you know why i take this stuff. i hurt my back and had four surgeries. it started there. i had pain so they fed me pain meds. Cymbalta and other antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment or when the dose is changed. STUCK taking Cymbalta because I can't bear to go through another withdrawal nor experience the suicidal ideations. There are no adequate and well-controlled studies of CYMBALTA administration in pregnant women. May cause a lowering of total body sodium called hyponatremia; elderly people or people taking diuretics or already dehydrated may be more at risk. After 7 weeks of treatment, CYMBALTA patients with less than 30% reduction in average daily pain and who were able to tolerate CYMBALTA 60 mg once daily had their dose of CYMBALTA, in a double-blinded fashion, increased to 120 mg once daily for the remainder of the study. Patients had a mean baseline pain rating of 6 on a numerical rating scale ranging from 0 no pain to 10 worst possible pain. After 13 weeks of treatment, patients taking CYMBALTA 60-120 mg daily had a significantly greater pain reduction compared to placebo. Notes: In general, seniors or children, people with certain medical conditions such as liver or kidney problems, heart disease, diabetes, seizures or people who take other medications are more at risk of developing a wider range of side effects. Now I had to really push myself. I went back to my Dr. and she said to stop taking it and come back in a month and see how I am. It has been four weeks, but right after quitting I cam down with a lung and sinus infection which knocked me out for two weeks. So I don't know what the withdrawal symptoms and what was my illness. Cymbalta for Major Depressive Disorder, Generalized Anxiety Disorder, and PTSD. This medication has rapidly stabilized my condition and greatly contributed to better mood regulation. In less than a week, Cymbalta alleviated suicidal thoughts and my level of distress in response to triggers. Some patients may experience withdrawal reactions such anxiety, nausea, nervousness, and insomnia.
However, TENS for chronic low is not recommended, according to the American Academy of Neurology AAN because its effectiveness has not been proven. What should I avoid while taking Cymbalta? If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. CYMBALTA in MDD and GAD clinical trials up to 36-weeks in length, in which most patients received 30-120 mg per day. How can I watch for and try to prevent suicidal thoughts and actions? I'm so glad I looked it up because I thought maybe I was having a brain stroke! If your primary doctor isn't able to help you control back pain, he or she may refer you to a back specialist or a pain specialist. Sometimes, these doctors will use injections of steroids or anesthetics directly into the back to help control the pain. In cases where there is a or pinching of the nerve from the spinal cord, surgery may be indicated. Food and Drug Administration. Cymbalta Duloxetine Hydrochloride Capsules. Detailed View: Safety Labeling Changes Approved By FDA Center for Drug Evaluation and Research CDER June 2015. Although these events are generally self-limiting, some have been reported to be severe. Over-the-counter painkillers such as acetaminophen Tylenol aspirin, or , can be helpful. Do not crush, chew, break, or open an extended-release capsule. Swallow it whole. Cymbalta, the instant withdrawal type mood swings and headaches would always remind me to get my Fix. I was happy with the drugs results at the start of my cycle, it helped me lower my extreme stress and sometimes panic attacks. But yeah, I don't think people start going into medications assuming they will stick with it for the rest of their life. Anyway, here I am only fourth day of no 30mg Cymbalta and feeling like a donkey roundhouse kicks my skull all the time. Since the first day of stopping, my brain zaps would often be overwhelmingly disorientating and I still can't bare to talk to people or go outside. Moving my eyes and head too fast or simply standing up can result in a zap to the head, making me stay in bed and sulking over why I even started the drug. I still get hungry quite often but will get queasy and nauseous, making me want to just starve. Any loud noises frighten me and have given me a slight tick, holding my ears shut and holding my breath to prepare my brain. I suppose the noises are very heightened and just feeds the headaches. The only relief I seem to get from this is sleep but I find myself extremely hot and uncomfortable in even cold conditions. Walking has become a chore and no aspirin or vitamin seems to help. I have earplugs to prepare me or walking into the city briefly tomorrow and hope I can feel normal again soon. I wish I were surprised to see so many with similar withdrawal issues, but I'm flabbergasted at how little doctors seem to care or entertain the idea of withdrawal and how to get through it. Best of luck to everyone and I really hope our voices can be heard before another patient becomes a victim. purchase coversyl high
buy now cheapest cymbalta pharmacy, canadian pharmacy cymbalta online, buy cymbalta 1mg tablets, purchase generic cymbalta pharmacy canada, cheap cymbalta on line, why no generic for cymbalta, cost cymbalta walmart, cymbalta price ireland, purchase cymbalta uk, order cymbalta pills online, cymbalta shop dublin, generic for cymbalta 750 mg, order cymbalta online usa, shop cymbalta otc, buy cymbalta shop uk, lloyds pharmacy cymbalta delivery, price cymbalta together, cymbalta buy europe, price of cymbalta 20 mg, cymbalta buy now pharmacy uk, brand cymbalta canadian pharmacy, order now cymbalta shopping, buy online cymbalta 120mg, cvs pharmacy cymbalta otc tablets, longs drugs cymbalta price, cheapest cymbalta buy pharmacy, generic cymbalta greece, order cymbalta forum, buy now cymbalta online, cost of cymbalta per month, order cymbalta online visa canada, cymbalta price in dubai, cymbalta codes, buy cymbalta payment australia, price cymbalta starter pack, cymbalta purchase online, brand cymbalta dosage, buy cymbalta together, cheap cymbalta order online shop, store cymbalta price, generic cymbalta uk suppliers, online cymbalta espana, generic cymbalta in canada, shop cymbalta uses, generic version cymbalta, cheap cymbalta alternatives uk, generic cymbalta ulotka, where can i buy cymbalta over the counter, buy now generic cymbalta shopping, cost of cymbalta forte dsc, cymbalta buy payment australia, cheap brand cymbalta 100mg, buy generic cymbalta online europe, generic cymbalta purchase mastercard australia, online clinic cymbalta, cheap cymbalta pharmaceuticals, online cymbalta reacoes, buy generic cymbalta from india online, buy cheap cymbalta online uk, can you buy cymbalta tablets in australia, cymbalta bangladesh shop, mail order cymbalta payment, buy cymbalta medication, buy cymbalta hawaii, buy cymbalta online europe, cymbalta store hawaii, brand cymbalta ulotka, cymbalta where to purchase australia, cymbalta purchase shopping uk, price cymbalta 50mg, cymbalta purchase uk, purchase cymbalta tablets online, generic cymbalta do, cymbalta online visa purchase, cymbalta purchase online store, brand cymbalta medication, buy now cymbalta shop europe, cymbalta price uk boots, where to buy cymbalta elixir, buy cymbalta online in canada, easy cymbalta, cymbalta price pharmacy, farmacia online cymbalta, brand cymbalta price, how to buy cymbalta pharmacy, buy cymbalta price, price cymbalta 500 mg walmart, cymbalta buy canada, purchase now cheap cymbalta visa, cymbalta order pharmacy uk, buy generic cymbalta shopping, purchase cymbalta high, discount cymbalta cena, price cymbalta dose pack, cymbalta generic prices, cymbalta alternative canada
Disclaimer: Every effort has been made to ensure that this information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This drug information does not endorse drugs, diagnose patients or recommend therapy. It is an informational resource designed as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugs.
Antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patients during the early phases of treatment. An increased risk of suicidal thinking and behavior in children, adolescents, and young adults aged 18 to 24 years with major depressive disorder MDD and other psychiatric disorders has been reported with short-term use of antidepressant drugs. Cymbalta is the second drug approved by the FDA to treat fibromyalgia. Nearly a year ago, the as the first drug treatment for fibromyalgia. Cymbalta as it worked well for me. But after these side effects I will never take it again and I plan to cold turkey through the withdrawal period. I certainly hope I am one of the "lucky" ones and don't have to go through this for months!
DSM-IV criteria for MDD at 2 consecutive visits at least 2 weeks apart, where the 2-week criterion had to be satisfied at only the second visit. The effectiveness of CYMBALTA in hospitalized patients with major depressive disorder has not been studied. Results of in vitro studies demonstrate that duloxetine does not inhibit or induce CYP3A activity. The use of MAOIs intended to treat psychiatric disorders with CYMBALTA or within 5 days of stopping treatment with CYMBALTA is contraindicated because of an increased risk of serotonin syndrome. It is not known if Cymbalta will harm your unborn baby. Talk to your healthcare provider about the benefits and risks of treating depression or other conditions with Cymbalta during pregnancy.
In postmarketing experience, fatal outcomes have been reported for acute overdoses, primarily with mixed overdoses, but also with duloxetine only, at doses as low as 1000 mg. Signs and symptoms of overdose duloxetine alone or with mixed drugs included somnolence, coma, serotonin syndrome, seizures, syncope, tachycardia, hypotension, hypertension, and vomiting. Check the labels on all your medicines such as or -and-cold products because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. Marketed by: Lilly USA, LLC, Indianapolis, IN 46285, USA.